Fig 1: Myeloid Vamp3 deletion reduced macrophage infiltration and inflammation progression in CFA-induced mice. (A), Representative images of immunohistochemical staining of the ipsilateral paw skins of WT and Vamp3 Δmyel mice with an anti-CD68 antibody at day 14 following CFA injection. Scale bars, 100 µm. (B), Representative images of the ipsilateral paw skin tissues of WT and Vamp3 Δmyel mice stained with HE at day 14 after CFA treatment. Scale bars, 50 µm. (C), Analysis of epidermal thickness of the ipsilateral plantar skins of WT and Vamp3 Δmyel mice by H&E staining at day 14 after CFA injection. Epidermal thickness was measured in 5 randomly selected fields of view per mouse. (D), Scores of inflammation in the ipsilateral hind paw tissues by H&E staining. Data in (C, D) are presented as mean ± SEM, n=6. *p < 0.05; unpaired two-tailed Student’s t-test.